Introducing the Industrial Scale Fermenter/Bioreactor

Take a look at the best solution to big-scale, high-efficient, and stable fermentation, the Fermentador/biorreactor a escala industrial that BaiLun Bio provides. The powerhouse will suit the needs of people who seek a high level of performance without concessions: it is a place where innovation in engineering and flexibility of operations meet the rigor of quality.

So why is this Fermentador/biorreactor a escala industrial the heartbeat to so many productive bioprocessing plants? So how about we examine up close.

The Industrial-Strength of Biotechnology

With any industrial manufacture of product, be it enzymes, vaccines, antibiotics, proteins, bio-based chemicals, the fermenter is more than a piece of equipment. It is that important link between raw materials and finished products.

The Industrial Scale Fermenter/Bioreactor is a specifically designed product to do this task that supports batch, fed batch or continuous operation and it can be sterile, efficient and reproducible. Envision a high quality, high power automation controlled design and flexibility in a fermenter but with an industry robust 5000L; and you have the dream come true. That is what we bring about.

What Is Important about Industrial-Scale Fermentation?

When it comes to the active field of biotechnology and industrial microbiology, the biggest challenge, to say the least, is making the necessary scale-up process from the laboratory bench to the full-scale production. A successful pilot run means nothing if your industrial system can’t replicate those results reliably. Here the Fermentador/biorreactor a escala industrial will perform the best, which is the integration of process control, rugged, and simple to clean and sterilize all in one solution.

Does your manufacturing line have problems such as contamination, uneven yields or energy wastage? Now, how does this bioreactor assist in breaking such boundaries?

The Outstanding Functions and Design

The philosophy of the design is straightforward for our Fermentador/biorreactor a escala industrial: no detail is too small, yet should have been optimized to support microbial or cell cultures with maximum productivity and safety. These are the important aspects of the design to consider:

  • 316/304 stainless steel jacketed tanks with polished service side to 0.4-0.6 microns to enable clearance and low contamination chance.
  • Advanced stirring systems (mechanical or magnetic) to handle different viscosity media and delicate cultures.
  • Fully automated SIP (sterilization in place) and CIP (cleaning in place) systems to reduce downtime.
  • Siemens PLC control and online control of real-time storage, monitoring of data and advanced control techniques.
  • Adjustable gas control covering Air, O2, N2 and CO2.

And now you will ask me how this can be of any practical assistance in training? Let us go more into details.

Technical Parameters

What makes the Fermentador/biorreactor a escala industrial a production ready solution is as follows:

ParámetroDdescripción
Volumen total5L, 10L, 15L, 20L, 30L, 50L, 100L, 200L, 500L, 1000L, 5KL, 50KL, 200KL, etc.
Volumen de trabajo30%~70%
TanqueTanque con camisa, fabricado con SS316 y SS304, presión de diseño del tanque de 0,3 Mpa, presión de diseño de la camisa de 0,35 Mpa, pulido de 0,4 a 0,6 um, relación de diámetro y altura de 1:2,2 a 2,5
Sistema de agitaciónAccionamiento mecánico en la parte superior/inferior o accionamiento magnético en la parte superior, paleta de seis hojas ajustable en altura de 3 piezas

Velocidad de agitación: 50~1000rpm/50-400rpm

EsterilizaciónEsterilizar en el lugar (SIP), control automático por programa
LimpioLimpieza in situ (CIP) mediante bola rociadora
control de gasesControl por medidor de rotor, caudal de aire 1 vvm
AlimentaciónAlimentación automática mediante bomba peristáltica.
Control antiespumanteAgregue antiespumante automáticamente mediante bomba peristáltica
Control de temperaturaAutocontrol, rango de calefacción eléctrica: la fuente de agua agrega 5 ℃ a 70 ℃
control de phPH 2,00-12,00±0,1, control automático de adición de ácido/base mediante bomba peristáltica, sensor de pH de Hamilton/Mettler, Suiza.
hacer control0-150±3% que muestra una precisión de 0,1%, sensor de OD de Hamilton/Mettler, Suiza. HACER acoplamiento con agitación, oxígeno.
MuestreoVálvula de muestreo, esterilización de botes por separado, manual.
CosechaVálvula inferior de zona muerta cero (Gemu/Burket, Alemania), esterilización de latas por separado, manual/automática
Sistema de elevación de tapa30L-500L tienen sistema de elevación de tapa, 700-1000L tienen agujero humano.
PresiónControl automático, transmisor de presión BD Alemania
EscapeDisponer de condensador antes del escape, control mediante válvula de diagrama/válvula de control proporcional.
Parámetros de controlPantalla táctil de 10 o 15 pulgadas, PLC Siemens con parámetros de control (agitación, pH, OD, temperatura, alimentación, alarma, gas, etc.), análisis de datos, registro de datos, salida de datos, idioma (RU/EN/CN) y otros personalizados. funciones
Configuración opcionalControl remoto, medidor de flujo másico (gas de control automático), O2/N2/CO2, flujo de gas 2vvm, análisis de escape de gas (CO2), sensor de nivel, sensor de turbidez (OD), sensor de ORP, sistema de peso, sensor de celda viva (biomasa) , Impresión, Pantalla táctil Siemens, Doble sello mecánico, Grupo de 4 válvulas para alimentación, Descarga automática de válvula inferior, Certificado ASME, Certificado CSA, Cultivo por lotes, Transferencia de semillas, etc.

Process Reliability: The Center-piece of Industrial Manufacture

Consider the bets: a contaminated 5000L fermenter will result in massive material loss and time wastage. Such issues are avoided by this system in the following way:

  • Many smooth inside welds and smooth polished interiors in order to avoid dead corners.
  • SIP and CIP systems that are completely automated with assurance of effective sterilization and cleaning.
  • Alarm system and sensor integration to detect the deviations in the process in real time.

Today, ask yourself how much money you would save only by eliminating even one case of contamination per year.

State-of-Art Automation and Control

El Fermentador/biorreactor a escala industrial does not only provide strong mechanical design, but it also provides the best control available in the industry:

  • The Siemens PLCs coupled with touch screens easy to use.
  • The parameters such as pH, DO, temperature and agitation speed could be monitored in real time.
  • Compliance and optimisation of process with data logging and export.
  • Automatic feeding and antifoam to get stable production.

This implies that your operators have to make fewer setting changes, and more time enhancing process results.

Flexible Stirring and Gas handling

The system is appropriate to both mechanical and magnetic stirring, all the way to highly viscous fungal cultures as well as shear-sensitive mammalian cells:

  • Sealed operation is guaranteed as there is magnetic coupling which minimizes the chances of any contamination.
  • Paddles are six bladed to maximize the mixing and oxygen transfer.
  • Gas control aids the sophisticated applications:
  • Inputs of air, oxygen, nitrogen and CO2.
  • Auto gas blending optional mass flow meters.
  • Exhaust condenser ensures that the products are not lost and minimizes vents.

Versatility and Scalability of Production

The BODREAD V2 system is a versatile and scalable medium-sized production grid. Regardless of the type of product you are yielding, antibiotics, amino acids, vaccines, or enzymes, the Fermentador/biorreactor a escala industrial is versatile on the basis of process modes:

  • Batch culture.
  • Fed-batch culture.
  • Continuous and perfusion system.

An optional module, such as live cell sensors, weight systems and ORP sensors, enables you to optimize your process.

Construction to World standards

The system is trans-national market oriented:

  • Options of certification to ASME and CSA.
  • Brand-name components; Siemens, Hamilton, Mettler, Gemu, Burket, and BD.
  • Interface language and Software customization.

Not only has been built to work-but to do it so well wherever you are operating.

The Energy efficiency and Sustainability

The cost of energy may be a huge challenge to profitability. There is a jacketed design and effective heating and cooling that save on thermal loss. The CIP system diminishes use of water and cleaning agent.

Consider this: what could happen to utility expenses should your fermenter cut on the cost of utilities without affecting performance?

Applications of It in the Real World

How are Fermentador/biorreactor a escala industrial used by the industries?

  • Vaccine manufacturing (human and veterinary).
  • The manufacture of enzymes into food and industry.
  • Organic acid and amino acids.
  • Antibiotic fermentation.
  • Recombinant proteins manufacture.

It is so versatile that it underpins both multinational production plants and the biotech startups.

Intuitive Operation: Operator based Design

Usability can provide to any system even the most advanced one:

  • Easy-to-read displays having 10-15inch touch screens.
  • Multi-lingual menu and graphical data presentations.
  • Monitoring remotely eliminates the requirement of people on the locations.
  • The curves of historical data are used to debug the processes and minimize flaws.

How many hours would your team have saved on a user-friendly system?

On-the-fly Safety and Compliance

Interlocked and built-in warnings safeguard your goods, machines and employees:

  • Overpressure automatic shut-to-off.
  • Alerts over temperature, pH and DO variances.
  • Convenience in export of data in regulatory audits.
  • Nothing unexpected except stable production.
  • Viable investment in the future

Your production requirements can increase. You can get the modular structure of the Industrial Scale Fermenter/Bioreactor:

  • Mass flow control as opposed to rotor meter.
  • Include exhausts gas analysis CO2.
  • Install level sensors, turbidity and biomass sensors.
  • Increase in single batch to seed transfer systems.
  • It is a system that is scalable with your business.

Why BaiLun Bio?

With decades of experience Biografía de BaiLun only supplies equipment:

  • Consulting and design of processes.
  • After sale services and training.
  • Globally shipping and set up.
  • Custom made remedies to unique use.

We understand fermentation isn’t just equipment, it’s your business.

Reflexiones finales

El Fermentador/biorreactor a escala industrial is not a product only. It is the man to:

  • Increases of the yields of products.
  • Unity in quality of batches.
  • Reduced downtimes and reduction of contamination.
  • Energy and resources efficiency.
  • Easy to use control.

Ask yourself the question: is your process more cost effective, prolific, and profitable with improved equipment?

It is time to make your production to the next level. Contacto BaiLun Biografía to understand how the Fermentador/biorreactor a escala industrial can create wonders in your operations.

Are you craving to grow with confidence? How about we create fermentation of the future.

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