Vaccine fermenter(GMP) Microbial Bioreactors

Fermenter Technical Parameters

Parameter	Description
Total volume	5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 2KL,5KL,10KL etc.
Working volume	30%~70%
Polishing	Electrolytic polishing, precision: 0.2-0.4um.
Stirring system	Mechanical drive or Magnetic drive, 3 height adjustable six – blade stirrer Stir speed: 50~1000rpm/50-350rpm
Sterilization	On-site sterilization(SIP) by auto control
Clean	Clean in place (CIP) by spray ball
Aeration flow	Multi-way ventilation. Auto control by mass flow meter, 1vvm
Feeding	Automatically feeding by fixed peristaltic pump (standard) Variable speed peristaltic pump(optional)
Anti-foam control	Automatically add antifoam by peristaltic pump
Temperature control	Auto-control, electric heating range: water source add 5℃ to 70℃
PH control	2.00-12.00±0.05pH, auto-control by adding acid and base, pH sensor (Hamilton/Mettler, Switzerland)
DO control	0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.
Sampling valve	Can sterilization separately, manual
Harvest	Zero dead zone bottom valve, can sterilization separately, manual
Weight system	Mettler-Toledo, Switzerland
Pressure	Auto control, BD Germany pressure transmitter or Lambert differential pressure liquid level gauge.
Exhaust	Have condenser before exhaust, control by diagram valve / Proportional control valve.
Control parameters	10in touch screen, Siemens PLC control system with control parameters (stirring, pH, DO, temperature, feeding, gas etc.), data analysis, data logging, data output and printing, overrun alarm, language switching and other functions
Optional configuration	O2/N2/CO2 gas control, Level sensor, OD sensor, Turbidity sensor, ORP sensor, Weight system, Live cell sensor etc.

Fermenter Description

Fully sealed, zero leakage, no pollution, and maintenance-free. The double-end mechanical seal completely solves the problem of bacterial contamination in biological product tanks. Various parameters during fermentation such as pH, DO, temperature and rotational speed can be monitored through the controller, and all data and control parameters can be transmitted to the controller or computer. Compact structure, various components can be integrated on the fermentation system. You can choose to use the direct coupling mechanical stirring method driven by the upper part or the magnetic indirect coupling mechanical stirring method driven by the lower part. The structure is simple and the operation is stable. Polishing precision Ra≤0.4.

German Siemens S7-200 series PLC control system + 10” LCD touch screen display operation, on-site direct operation (menu type), full English menu and interface; sampling and display of tank data, browsing and analysis of system data, and reading settings. Available Control the stirring speed, the temperature of the medium in the tank, Ph value, DO value.

Fermenter Application

1. Animal vaccine production: Avian influenza vaccine, Porcine PRRS vaccine, Foot-and-mouth disease, Rabies vaccine, Mink vaccine, DTP vaccine, Diphtheria vaccine, Tetanus vaccine, etc.
2. Human vaccine production: Diphtheria vaccine, Tetanus vaccine, Meningitis vaccine, Pneumonia IV vaccine, Hepatitis B vaccine, etc.
3. Culture for microorganism (bacterial,fungi,yeast.etc), mammalian cell(293,CHO etc.), plant cell, algae, enzyme, protein, additives, antibiotics etc.