2000L Multi-stage Industrial Bioreactor

Industrial Bioreactor Flexible Design: Work Independently or in Combination

It is a rare occasion that modern day fermentation is carried out in a single tank. That is why 2000L Multi-stage Industrial Bioreactor deals with:

• Multi-step installation: tanks can be used individually or linked together one to another
• Reliable, sterile transplantation pipelines between tanks
• Floor or bench based racks to suit your plant system
• Separate or centralized Siemens PLC control cabinets

Consider beginning your fermentation process on a seed fermenter followed by a smooth transition to larger and larger tanks all the way to production in an uncompromised way between sterility and efficiency.

Would you like to have multi-stage option in your process?

Industrial Bioreactor Technical Parameters

Parámetro	Ddescripción
Volumen total	5L, 10L, 15L, 20L, 30L, 50L, 100L, 200L, 500L, 1000L, 5KL, 50KL, 200KL, etc.
Volumen de trabajo	30%~70%
Tanque	Tanque con camisa, fabricado con SS316 y SS304, presión de diseño del tanque de 0,3 Mpa, presión de diseño de la camisa de 0,35 Mpa, pulido de 0,4 a 0,6 um, relación de diámetro y altura de 1:2,2 a 2,5
Sistema de agitación	Accionamiento mecánico en la parte superior/inferior o accionamiento magnético en la parte superior, paleta de seis hojas ajustable en altura de 3 piezas Velocidad de agitación: 50~1000rpm/50-400rpm
Esterilización	Esterilizar en el lugar (SIP), control automático por programa
Limpio	Limpieza in situ (CIP) mediante bola rociadora
control de gases	Control por medidor de rotor, caudal de aire 1 vvm
Alimentación	Alimentación automática mediante bomba peristáltica.
Control antiespumante	Agregue antiespumante automáticamente mediante bomba peristáltica
Control de temperatura	Autocontrol, rango de calefacción eléctrica: la fuente de agua agrega 5 ℃ a 70 ℃
control de ph	PH 2,00-12,00±0,1, control automático de adición de ácido/base mediante bomba peristáltica, sensor de pH de Hamilton/Mettler, Suiza.
hacer control	0-150±3% que muestra una precisión de 0,1%, sensor de OD de Hamilton/Mettler, Suiza. HACER acoplamiento con agitación, oxígeno.
Muestreo	Válvula de muestreo, esterilización de botes por separado, manual.
Cosecha	Válvula inferior de zona muerta cero (Gemu/Burket, Alemania), esterilización de latas por separado, manual/automática
Sistema de elevación de tapa	30L-500L tienen sistema de elevación de tapa, 700-1000L tienen agujero humano.
Presión	Control automático, transmisor de presión BD Alemania
Escape	Disponer de condensador antes del escape, control mediante válvula de diagrama/válvula de control proporcional.
Parámetros de control	Pantalla táctil de 10 o 15 pulgadas, PLC Siemens con parámetros de control (agitación, pH, OD, temperatura, alimentación, alarma, gas, etc.), análisis de datos, registro de datos, salida de datos, idioma (RU/EN/CN) y otros personalizados. funciones
Configuración opcional	Control remoto, medidor de flujo másico (gas de control automático), O2/N2/CO2, flujo de gas 2vvm, análisis de escape de gas (CO2), sensor de nivel, sensor de turbidez (OD), sensor de ORP, sistema de peso, sensor de celda viva (biomasa) , Impresión, Pantalla táctil Siemens, Doble sello mecánico, Grupo de 4 válvulas para alimentación, Descarga automática de válvula inferior, Certificado ASME, Certificado CSA, Cultivo por lotes, Transferencia de semillas, etc.

Why Choose Stainless Steel for Industry-Scale Fermentation?

When you’re producing at 2000 liters or more, every weld, seal, and valve matters. It has SS316L and SS304 stainless steel constructed fermenter tank:

• Superior corrosion resistance to withstand acids and bases
• Polished internal surfaces (0.4–0.6μm) to reduce contamination risk
• No dead zones with rounded corners and a customized practice of welding
• High design pressure for processes demanding temperature swings

Do your existing tanks have a design that is designed to last 100 days a day?

Intelligent Mixing: Stirring & Gas Flow in Harmony

• Each batch has unique shear, oxygen, and mixing needs.
• As an industry fermenter, select the Multi-stage stainless steel 2000L.
• Top or bottom mechanical drives
• Magnetic drive option (top) for reduced contamination risk
• 3 heights‑adjustable six‑blade paddles
• Wide stir speed range (50–1000rpm)

Combined with gas flow control (rotor meter, 1 vvm standard; mass flow optional), you get fine-tuned oxygen transfer for cell cultures, yeast, or bacteria.

Temperature & pH Under Precise Control

Correct control is not a luxury; it is the grant to reproducibility.

✅ Auto‑controlled electric heating

✅ Wide range: +5℃ to 70℃

✅ Siemens PLC‑driven pH control: pH 2.00–12.00 ±0.1

✅ Sensors from Hamilton/Mettler for reliability

Stable temperature + pH = consistent product quality.

Sterility by Design: SIP & CIP

Contamination can ruin days, or weeks, of work.

With this system:

• SIP:Sterilization in place, automated
• CIP:Cleaning in place, spray ball ensures full coverage
• Sterile sampling & harvest valves:can be sterilized separately
• Sterile filtration:2μm filters prevent backflow

How much time (and risk) could you save with true SIP & CIP?

Siemens Automation: Control, Monitor, Optimize

Run the fermenter through:

• 10” or 15” color touchscreen
• Siemens S7-200 PLC
• On‑screen trends, alarms, and data export
• Multilingual menus (RU/EN/CN)
• Optional remote monitoring & batch recording

Upgrades? Include live cell sensors, ORP, turbidity, exhaust CO 2 analysis and so on.

Typical Applications: Animal & Human Vaccines, Bio‑production

Imagine the scale:

• Animal vaccines:PRRS, rabies, mink, DTP, tetanus
• Human vaccines:hepatitis B, pneumonia, meningitis
• Biotech:enzymes, proteins, antibiotics, probiotics
• Culture:bacteria, yeast, fungi, CHO / 293 Cells, algae, plant cells

El 2000L Multi-stage Industrial Bioreactor is the interpreter between pilot and production.

A True Multi‑stage System: Why It Matters

With multi-stage setups, you can:

• Propagate seed cultures to a grow condition in 1/10th of production scale tanks → scale up to production
• Reduce contamination risk (separate sterilization)
• Scale process while keeping control over each step
• Floor-standing or bench-mounted; separate or centralized control.

Will dividing your process in stages increase yield and cut failure rate?

Built to Last, Designed for Safety

• German BD pressure transmitters for precise control
• Large viewing glass & 12V safe lighting
• Sampling / inoculation / feeding ports + spares
• Optimized flow design = uniform temperature & nutrient mixing
• Polished welds: strong, clean, and hygienic

What Comes Standard?

✅ Fully jacketed 2000L SS316L/304 tank

✅ Mechanical / magnetic stirring system

✅ Siemens PLC + touchscreen

✅ Hamilton/Mettler sensors (pH & DO)

✅ CIP & SIP functions

✅ Peristaltic pumps for feed & antifoam

✅ Rotor meter for gas flow

✅ Sampling & harvest valves

✅ Exhaust condenser & valves

✅ Documentation & training

Customization: Because Every Process is Different

Agregar:

• Mass flow meters for automated gas blending
• O₂, N₂, CO₂ control lines
• Remote monitoring & batch data export
• Auto discharge valves & bottom valves
• ASME/CSA certification
• Batch culture & seed transfer software
• ORP, turbidity, biomass sensors

Let us design your perfect setup.

Why choose BaiLun Bio?

✅ 10+ years serving global biotech & pharma

✅ Siemens automation as standard

✅ CE / ISO / ASME certified designs

✅ Stainless steel built for longevity

✅ Support & spare parts worldwide

✅ Flexible to scale with your needs

From Lab Bench to Production

Start with 5–10L, then move to 2000L, all with consistent:

• Automatización
• Control logic
• Sensor technology
• Same platform, easier scale-up, faster time to market.

Imagine the Possibilities

What if you could:

• Reduce contamination events by 80%?
• Cut cleaning time in half?
• Double yield consistency batch-to-batch?

That’s the value behind engineering, not just volume.

Ready to redefine your process?

Discover 2000L Multi-stage Industrial Bioreactor now.

• Visit BaiLun Bio
• Request a quote
• Ask technical questions
• Discuss your process needs

The future of controlled, large‑scale fermentation starts here.