2000L Multi-stage Industrial Bioreactor

Industrial Bioreactor Flexible Design: Work Independently or in Combination

It is a rare occasion that modern day fermentation is carried out in a single tank. That is why 2000L Multi-stage Industrial Bioreactor deals with:

• Multi-step installation: tanks can be used individually or linked together one to another
• Reliable, sterile transplantation pipelines between tanks
• Floor or bench based racks to suit your plant system
• Separate or centralized Siemens PLC control cabinets

Consider beginning your fermentation process on a seed fermenter followed by a smooth transition to larger and larger tanks all the way to production in an uncompromised way between sterility and efficiency.

Would you like to have multi-stage option in your process?

Industrial Bioreactor Technical Parameters

范围	D描述
总容积	5L、10L、15L、20L、30L、50L、100L、200L、500L、1000L、5KL、50KL、200KL等
工作量	30%~70%
坦克	夹套罐，材质为SS316、SS304，罐体设计压力0.3Mpa，夹套设计压力0.35Mpa，抛光0.4-0.6um，直径与高度之比为1：2.2-2.5
搅拌系统	顶部/底部机械驱动或顶部磁力驱动，3 个高度可调的六叶片桨 搅拌速度：50~1000rpm/50-400rpm
消毒	就地灭菌（SIP），程序自动控制
干净的	通过喷球就地清洗 (CIP)
气体控制	由转子流量计控制，气流 1 vvm
喂养	蠕动泵自动加料
消泡控制	通过蠕动泵自动添加消泡剂
温度控制	自动控制、电加热范围：水源加5℃至70℃
PH值控制	PH 2.00-12.00±0.1，蠕动泵自动控制加酸/加碱，瑞士Hamilton/Mettler pH传感器。
做好控制	0-150±3% 显示精度0.1%，DO传感器来自瑞士Hamilton/Mettler。 DO 与搅拌、氧气偶联。
采样	取样阀，可单独灭菌，手动
收成	零死区底阀（德国Gemu/Burket），可单独灭菌，手动/自动
盖子升降系统	30L-500L有盖子升降系统，700-1000L有人孔。
压力	自动控制，德国BD压力变送器
排气	排气前有冷凝器，由图表阀/比例控制阀控制。
控制参数	10或15英寸触摸屏，西门子PLC，具有控制参数（搅拌、pH、DO、温度、进料、报警、气体等）、数据分析、数据记录、数据输出、语言（RU/EN/CN）等定制功能
可选配置	远程控制、质量流量计（自动控制气体）、O2/N2/CO2、气体流量2vvm、气体（CO2）废气分析、液位传感器、浊度（OD）传感器、ORP传感器、称重系统、活细胞传感器（生物质） , 打印, 西门子触摸屏, 双机械密封, 4阀组喂料, 底阀自动卸料, ASME证书, CSA证书, 批量培养, 种子转移等。

Why Choose Stainless Steel for Industry-Scale Fermentation?

When you’re producing at 2000 liters or more, every weld, seal, and valve matters. It has SS316L and SS304 stainless steel constructed fermenter tank:

• Superior corrosion resistance to withstand acids and bases
• Polished internal surfaces (0.4–0.6μm) to reduce contamination risk
• No dead zones with rounded corners and a customized practice of welding
• High design pressure for processes demanding temperature swings

Do your existing tanks have a design that is designed to last 100 days a day?

Intelligent Mixing: Stirring & Gas Flow in Harmony

• Each batch has unique shear, oxygen, and mixing needs.
• As an industry fermenter, select the Multi-stage stainless steel 2000L.
• Top or bottom mechanical drives
• Magnetic drive option (top) for reduced contamination risk
• 3 heights‑adjustable six‑blade paddles
• Wide stir speed range (50–1000rpm)

Combined with gas flow control (rotor meter, 1 vvm standard; mass flow optional), you get fine-tuned oxygen transfer for cell cultures, yeast, or bacteria.

Temperature & pH Under Precise Control

Correct control is not a luxury; it is the grant to reproducibility.

✅ Auto‑controlled electric heating

✅ Wide range: +5℃ to 70℃

✅ Siemens PLC‑driven pH control: pH 2.00–12.00 ±0.1

✅ Sensors from Hamilton/Mettler for reliability

Stable temperature + pH = consistent product quality.

Sterility by Design: SIP & CIP

Contamination can ruin days, or weeks, of work.

With this system:

• SIP:Sterilization in place, automated
• CIP:Cleaning in place, spray ball ensures full coverage
• Sterile sampling & harvest valves:can be sterilized separately
• Sterile filtration:2μm filters prevent backflow

How much time (and risk) could you save with true SIP & CIP?

Siemens Automation: Control, Monitor, Optimize

Run the fermenter through:

• 10” or 15” color touchscreen
• Siemens S7-200 PLC
• On‑screen trends, alarms, and data export
• Multilingual menus (RU/EN/CN)
• Optional remote monitoring & batch recording

Upgrades? Include live cell sensors, ORP, turbidity, exhaust CO 2 analysis and so on.

Typical Applications: Animal & Human Vaccines, Bio‑production

Imagine the scale:

• Animal vaccines:PRRS, rabies, mink, DTP, tetanus
• Human vaccines:hepatitis B, pneumonia, meningitis
• Biotech:enzymes, proteins, antibiotics, probiotics
• Culture:bacteria, yeast, fungi, CHO / 293 Cells, algae, plant cells

这 2000L Multi-stage Industrial Bioreactor is the interpreter between pilot and production.

A True Multi‑stage System: Why It Matters

With multi-stage setups, you can:

• Propagate seed cultures to a grow condition in 1/10th of production scale tanks → scale up to production
• Reduce contamination risk (separate sterilization)
• Scale process while keeping control over each step
• Floor-standing or bench-mounted; separate or centralized control.

Will dividing your process in stages increase yield and cut failure rate?

Built to Last, Designed for Safety

• German BD pressure transmitters for precise control
• Large viewing glass & 12V safe lighting
• Sampling / inoculation / feeding ports + spares
• Optimized flow design = uniform temperature & nutrient mixing
• Polished welds: strong, clean, and hygienic

What Comes Standard?

✅ Fully jacketed 2000L SS316L/304 tank

✅ Mechanical / magnetic stirring system

✅ Siemens PLC + touchscreen

✅ Hamilton/Mettler sensors (pH & DO)

✅ CIP & SIP functions

✅ Peristaltic pumps for feed & antifoam

✅ Rotor meter for gas flow

✅ Sampling & harvest valves

✅ Exhaust condenser & valves

✅ Documentation & training

Customization: Because Every Process is Different

添加：

• Mass flow meters for automated gas blending
• O₂, N₂, CO₂ control lines
• Remote monitoring & batch data export
• Auto discharge valves & bottom valves
• ASME/CSA certification
• Batch culture & seed transfer software
• ORP, turbidity, biomass sensors

Let us design your perfect setup.

Why choose BaiLun Bio?

✅ 10+ years serving global biotech & pharma

✅ Siemens automation as standard

✅ CE / ISO / ASME certified designs

✅ Stainless steel built for longevity

✅ Support & spare parts worldwide

✅ Flexible to scale with your needs

From Lab Bench to Production

Start with 5–10L, then move to 2000L, all with consistent:

• 自动化
• Control logic
• Sensor technology
• Same platform, easier scale-up, faster time to market.

Imagine the Possibilities

What if you could:

• Reduce contamination events by 80%?
• Cut cleaning time in half?
• Double yield consistency batch-to-batch?

That’s the value behind engineering, not just volume.

Ready to redefine your process?

Discover 2000L Multi-stage Industrial Bioreactor now.

• Visit BaiLun Bio
• Request a quote
• Ask technical questions
• Discuss your process needs

The future of controlled, large‑scale fermentation starts here.