100 Liter mammalian cell fermenter BLBIO-100SCUC

Have you ever wondered how it would feel to operate your mammalian cell cultures by the use of equipment that promises reproducible results, precision control, and endures the demands of current high technology biotechnology? Let’s dive in.

An Introduction to Modern Fermentation Excellence

这 100 Liter mammalian cell fermenter BLBIO-100SCUC is purpose-built to support the complex requirements of mammalian cell culture, including hybridoma cells, CHO cells, insect cells, and many others. With the battle between reproducibility and process efficiency deciding who wins the race against research and industrial production in the world of biotech nowadays, this fermenter stands the difference.

Designed with the best structural attributes, it offers ultra-performance and has features that meet functionality, adaptability, and ease of use.

Why Choose the Stainless Steel Design?

 

This fermenter is made of high quality 316L stainless steel featuring 304 stainless steel clips and provides the following:

• High corrosion resistance, critical for cleanroom and GMP environments.
• Internal surface with polished finish of 0.2-0.4um, allowed a reduced chance of contamination and easy cleaning.
• Polishing the surface in order to come up with the beauty of a professional finish that shows quality.
• The level of smart design it flaunts (blind spots are avoided, even within the tank) make it easier to clean to keep it sterile between run batches and shorten downtime.

Are you wasting your time as far as maintaining and cleaning are concerned? A smarter tank design could save you hours.

Performance Driven by Precise Engineering

At the heart of the 100 Liter mammalian cell fermenter BLBIO-100SCUC is a suite of features engineered for performance:

• Low shear mixing blades eliminate the possibility of damage to small cells such as delicate mammalian cells, which is a major advantage of this method of stirring.
• It has variable stirring speed of 30 -300 rpm which complies with varying culture demands.
• The occurrence of contamination is also minimized by the integrated cooling systems and exhaust pathways which have a special designed exhaust pipe ensuring the purity of your cultures.

Does your system right now safeguard your cell integrity when you mix it? This fermenter is built to do exactly that.

Control Systems for Complete Process Oversight

The Siemens S7-200 series PLC and large touch screen interface (10 or 15 inches) provide:

• Availability of real time information and room to perform necessary adjustments such as pH, DO, temperature, and gas flow among others.
• Full menu-driven operation in English, Russian, or Chinese.
• Instead, its strong data logging and data analysis capabilities that transform raw data into the actionable ones.

Whole new level of confidence when you can see the performance of your processes on your crystal clear interface, and warnings when important parameters are drifting. Wouldn’t that simplify your daily operation?

Key Specifications You Can Trust

Let’s explore the technical heart of the 100 Liter mammalian cell fermenter BLBIO-100SCUC:

范围	D描述
总容积	5L、10L、15L、20L、30L、50L、100L、200L、500L、1000L、5KL、10KL等
工作量	30%~70%
坦克	内部电解抛光，精度：0.2-0.4um。 直径与高度比1:1.5
搅拌系统	磁力驱动、低剪切搅拌叶片。搅拌速度：30~300rpm
消毒	就地灭菌（SIP），程序自动控制
干净的	用喷球清洁到位
气体控制	可混合至少四种气体（空气、氧气、氮气和二氧化碳） 质量流量计自动控制。空气流量 1vvm，O2/N2/CO2 0.1vvm。
喂养	蠕动泵自动加料
消泡控制	蠕动泵自动添加消泡剂
温度控制	自动控制、电加热范围：水源加5℃至70℃
PH值控制	PH 2.00-12.00±0.1，蠕动泵自动控制加酸/加碱，瑞士Hamilton/Mettler pH传感器。
做好控制	0-150±3% 显示精度0.1%，DO传感器来自瑞士Hamilton/Mettler。 DO 与搅拌、氧气偶联。
取样阀	可单独灭菌，手动
收成	零死区底阀，可单独灭菌，手动
重量系统	瑞士梅特勒-托利多
压力	自动控制，德国BD压力变送器或朗伯差压液位计。
排气	排气前有冷凝器，由图表阀/比例控制阀控制。
控制参数	10或15英寸触摸屏，西门子PLC，具有控制参数（搅拌、pH、DO、温度、进料、报警、气体等）、数据分析、数据记录、数据输出、语言（RU/EN/CN）等定制功能
可选配置	远程控制、质量流量计（自动控制气体）、排气加热、排气过滤器、气体（CO2）排气分析、液位传感器、浊度（OD）传感器、ORP传感器、称重系统、活细胞传感器（生物质）、打印、西门子触摸屏、双端面机械密封、四阀组进料、自动底阀、ASME证书、CSA证书、风量2vvm等

A System Designed to Adapt

In biotechnology, your needs can change rapidly. The 100 Liter mammalian cell fermenter BLBIO-100SCUC offers modular options:

• Remote control to manage your process anywhere.
• sophisticated sensors with which to measure the density of live cell density, ORP, or turbidity.
• Exhaust gas analysis for deeper process understanding.
• Custom bottom valves or multi-feed lines of difficult processes.

What would you do, were your process to change tomorrow and could your equipment keep up?

Safety and Reliability First

Safety features include:

• Zero dead zone bottom valve, eliminating residue accumulation.
• Sterilization-separable systems of manual sampling and harvest.
• Pressure sensors and safety lamps that enhance monitoring.

So with these the system does not merely work, it works safely batch after batch.

Applications That Go Beyond the Ordinary

Where can you use the 100 Liter mammalian cell fermenter BLBIO-100SCUC?

• Production of monoclonal antibodies from hybridoma cells.
• Recombinant protein drug manufacturing with CHO cells.
• Viral vaccine production through high-density culture.
• Academic research and pilot-scale testing before industrial scale-up.

Be it expands or using new cell lines, this fermenter helps.

Why Gentle Mixing Matters?

In mammalian cells, the shear stress may damage the quality and the viability of the product. The magnetic drive mixing system provides:

• Smooth, low-shear mixing ideal for suspension cell cultures.
• Uniform distribution of nutrients and gases.
• Flexibility to adapt speeds as cell density changes.

Do you struggle with low viability or inconsistent yields? A properly designed mixing system makes the difference.

Built for Sterility and Compliance

Using CIP and SIP systems: the fermenter will always be available to your next run:

• Automated cleaning and sterilization reduce manual work.
• Compliant design helps meet GMP requirements.
• Smooth, polished surfaces leave nowhere for contaminants to hide.

Could automated cleaning reduce your downtime and increase output?

User-Friendly Digital Platform

Siemens control system helps more than sustaining processes:

• Historical curve analysis helps spot trends.
• Alarm systems alert you before problems escalate.
• Data export keeps your quality records audit-ready.

Consider yourself having to answer questions with real-time and past data – quicker, more confident.

External Design Details That Matter

External design isn’t just aesthetic:

• Large sight glasses provide visual confirmation of liquid levels.
• Delay-type Philips safety lamps improve visibility during operation.
• Optimized exhaust systems protect against contamination and save heat.

Would not these be convenient features that would make your daily operation smooth and safe?

Supporting Large-Scale Production

The design isn’t just for lab-scale work:

• It scales seamlessly to 5KL, 10KL, and beyond.
• The same core control philosophy and quality materials.
• Modular configurations keep your facility ready for tomorrow’s demand.

Ready to grow your process? This fermenter grows with you.

The Power of Data in Your Hands

Data transforms fermentation from art into science:

• Record all pH, all gas and temperature changes.
• Use built-in analytics to refine your next batch.
• Reduce variability and enhance consistency.

Did you think about the possibility of better data to double your reproducibility and yields?

Precision Meets Flexibility

Every process is unique, and your fermenter should adapt:

• Switch between batch, fed-batch, or perfusion processes.
• Configure gas mixes dynamically.
• Adjust feeding strategies for growth and production phases.

How much more would your team be able to do with that sort of leeway?

支持

百伦生物 offers:

• Ongoing technical support.
• Customization services to match your process.

Try not to think about purchasing equipment per se, but having a stakeholder who will wish and take care of your success.

Sustainability in Bioprocessing

The fermenter helps sustainability by:

• Lowering energy costs through efficient heating/cooling.
• Minimizing product losses with better monitoring.
• Extending lifespan with robust stainless steel construction.

How would increase sustainability of operations affect your profits?

In Summary: Why Invest in This Fermenter?

• Robust 316L stainless steel design.
• Smart mixing for fragile mammalian cells.
• Advanced Siemens PLC with user-friendly interface.
• Flexible configurations and modular expansion.
• Proven track record in vaccine, antibody, and protein production.

Wouldn’t your process benefit from such reliability and control?

Make Your Next Step

这 100 Liter mammalian cell fermenter BLBIO-100SCUC isn’t just equipment; it’s your partner in pushing bioprocess limits, improving yields, and ensuring consistent, reproducible results.

Ready to elevate your cell culture process? 联系百伦生物 now and find out how this fermenter meets your requirements – and get on the way to smarter, more efficient, and scalable bio manufacturing.