100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB

Designed to Outperform: Why Choose Bottom Mechanically Agitated Fermenter?

• All stainless-steel 316L durable, polished stainless steel with hygienic design.
• Bottom mechanical stirring- provides stable and even mixing, which is ideal in a variety of cultures.
• Completely automated control system powered with Siemens PLC and working on the touchscreen.
• Clean-in-place (CIP) & sterilize-in-place (SIP), save time, reduce contamination risk.
• Adaptable applications, Fits well with bacteria, yeast, fungus, mammalian and plant cells, vaccines, enzymes and so on.

Have you ever experienced any process challenge of inconsistent temperature or oxygen flow? The design of diversion and bottom stirring on this fermenter makes it uniform within the vessel.

Fermenter Description: What Sets the 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter Apart?

这 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB isn’t just about volume. With its superior capabilities, it is famous among biotechnology and pharmacology specialists:

• Corrosion resistant and simple to clean, all stainless steel 316L tank body.
• Steam sterilized: is seen to last longer and offer superior protection through its double mechanical seal.
• Special sampling & discharging valves for aseptic processes.
• Large viewing glass for real-time observation.
• Integrated ports for temperature, pH, DO sensors, and feeding/inoculation.
• Optimized diversion design for better temperature and nutrient distribution.
• Air distributor and precision rotameter for accurate gas flow.

All welds are done to be strong, neat and fine polished to 0.4-0.6um – the epitome of beauty and utility.

Fermenter Technical Specifications

Every performance and reliability that you require, at one glance:

Bottom Mechanically Agitated Fermenter 技术参数：

范围	D描述
总容积	5L、10L、15L、20L、30L、50L、100L、200L、500L、1000L、5KL、50KL、200KL等
工作量	30%~70%
坦克	夹套罐，材质为SS316、SS304，罐体设计压力0.3Mpa，夹套设计压力0.35Mpa，抛光0.4-0.6um，直径与高度之比为1：2.2-2.5
搅拌系统	顶部/底部机械驱动或顶部磁力驱动，3 个高度可调的六叶片桨 搅拌速度：50~1000rpm/50-400rpm
消毒	就地灭菌（SIP），程序自动控制
干净的	通过喷球就地清洗 (CIP)
气体控制	由转子流量计控制，气流 1 vvm
喂养	蠕动泵自动加料
消泡控制	通过蠕动泵自动添加消泡剂
温度控制	自动控制、电加热范围：水源加5℃至70℃
PH值控制	PH 2.00-12.00±0.1，蠕动泵自动控制加酸/加碱，瑞士Hamilton/Mettler pH传感器。
做好控制	0-150±3% 显示精度0.1%，DO传感器来自瑞士Hamilton/Mettler。 DO 与搅拌、氧气偶联。
采样	取样阀，可单独灭菌，手动
收成	零死区底阀（德国Gemu/Burket），可单独灭菌，手动/自动
盖子升降系统	30L-500L有盖子升降系统，700-1000L有人孔。
压力	自动控制，德国BD压力变送器
排气	排气前有冷凝器，由图表阀/比例控制阀控制。
控制参数	10或15英寸触摸屏，西门子PLC，具有控制参数（搅拌、pH、DO、温度、进料、报警、气体等）、数据分析、数据记录、数据输出、语言（RU/EN/CN）等定制功能
可选配置	远程控制、质量流量计（自动控制气体）、O2/N2/CO2、气体流量2vvm、气体（CO2）废气分析、液位传感器、浊度（OD）传感器、ORP传感器、称重系统、活细胞传感器（生物质） , 打印, 西门子触摸屏, 双机械密封, 4阀组喂料, 底阀自动卸料, ASME证书, CSA证书, 批量培养, 种子转移等。

Smart Control with Siemens PLC

Imagine having every critical parameter at your fingertips.

• This fermenter incorporates a German Siemens S7-200 type PLC with a 10-inch LCD touchscreen:
• View real-time data (pH, DO, temp, stirring speed, gas flow)
• Automatic process control
• Historical data logging & export
• User-friendly interface in English, Chinese, and more
• Menu-driven navigation for fast learning curve

Tired of manual adjustments? Under automated control you concentrate on the results rather than on continuous watching.

Fermenter Applications

这 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB can be used:

Animal vaccine production:

• Avian influenza, PRRS, foot-and-mouth, rabies, mink vaccines
• DTP, diphtheria, tetanus

Human vaccines:

Meningitis, pneumonia IV, hepatitis B, diphtheria, tetanus

Other Fermentation Processes:

• Bacterial, fungal & yeast cultures
• Mammalian cell lines (CHO, HEK293)
• Plant cells, algae, enzymes, proteins
• Antibiotics, food additives

It can be used successfully on R&D to pilot scale due to its perfect mixture and temperature control.

Bottom Mechanical Stirring: Why It Matters

Bottom mechanical stirring ensures:

• Even distribution of heat and nutrients
• Reduced vortexing compared to top drives
• Better control for shear-sensitive organisms
• Stability at varying volumes

Ever wondered if bottom stirring fits your process? In cases in which your product will work best under even conditions, bottom stirring can be of great benefit.

 Gas & Ventilation: Deep Ventilation Done Right

• Integrated air distributor spreads gas evenly.
• Rotameter allows fine-tuned manual gas adjustment.
• Sterilizing filters (Dominic/Shanghai Yiming) with 0.2μm pore prevent contamination.
• Steam sterilized condensate cooling keeps seals lubricated and safe.
• Outcome: improved oxygen transfers rate, safer usage and a longer equipment functioning life.

Engineered for Hygiene & Durability

• All internal welds are smooth & neat.
• Polished to Ra ≤ 0.4–0.6μm, reducing contamination risk.
• Steam sterilization with automatic temperature control.
• 2-mechanical seal cooled & lubricated steam condensate.

The design reduces the time of cleaning and maintains low batch-to-batch contamination.

Process Optimization & Scalability

这 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB is a laboratory-scale up unit:

• Equal geometry and mixing at various volumes, processes can be easily validated.
• Data logging helps refine your protocols over time.
• Remote access options let you monitor anywhere.

Ready to move from lab to pilot? This one is your over-bridge that builds 5L to 200KL systems, each one as detailed as the other.

Optional Configurations & Custom Features

Customize your fermenter to match your exact needs:

• Mass flow meter for automatic gas mixing
• CO₂ exhaust gas analysis
• Turbidity, biomass & ORP sensors
• Automatic bottom valve discharge
• Batch culture & seed transfer modes
• Double mechanical seals & 4-valve feeding groups
• Certificates: ASME, CSA for Regulatory Compliance

Such adaptability maintains your investment up to date as your process changes in the future.

 Sustainable Bioprocessing Benefits

• Lower water & cleaning agent consumption with CIP/SIP.
• Energy-efficient design.
• High durability reduces replacement needs.

By investing on quality equipment, the lifecycle cost decreases and the unscheduled startup is minimized.

Intelligent Design Features

• Large viewing window & internal light.
• Liquid level interfaces and multiple spare ports.
• Compact footprint with lid lift system.
• Zero dead zone valve for full drainage.

All of this makes your work efficient and your data reliable.

Real-World Results: What You Can Produce?

• Recombinant proteins & enzymes
• Vaccines (viral & bacterial)
• Cell culture-based products
• Algal biomass
• Organic acids & amino acids
• Antibiotics & therapeutic proteins

The fermenter is flexible regardless of whether you need food, pharma, or research products.

Quick Recap: Why It Stands Out

• Robust stainless steel build
• Bottom mechanical stirring for stable, even mixing
• Automated Siemens PLC control
• CIP & SIP for top hygiene
• Flexible volumes and applications
• Global sensor & valve brands (Hamilton, Gemu, BD, etc.)

100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB is not only just a machine, it is a heart of your bioprocess lab.

Ready to Upgrade Your Fermentation?

Think even quicker scale-up, reduced contamination threat and wiser management of each batch.

Become familiar with 百伦生物, visit the company at the given contact, call today to discuss or have a quote tailored to your own requirements.