100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB

Designed to Outperform: Why Choose Bottom Mechanically Agitated Fermenter?

• All stainless-steel 316L durable, polished stainless steel with hygienic design.
• Bottom mechanical stirring- provides stable and even mixing, which is ideal in a variety of cultures.
• Completely automated control system powered with Siemens PLC and working on the touchscreen.
• Clean-in-place (CIP) & sterilize-in-place (SIP), save time, reduce contamination risk.
• Adaptable applications, Fits well with bacteria, yeast, fungus, mammalian and plant cells, vaccines, enzymes and so on.

Have you ever experienced any process challenge of inconsistent temperature or oxygen flow? The design of diversion and bottom stirring on this fermenter makes it uniform within the vessel.

Fermenter Description: What Sets the 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter Apart?

The 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB isn’t just about volume. With its superior capabilities, it is famous among biotechnology and pharmacology specialists:

• Corrosion resistant and simple to clean, all stainless steel 316L tank body.
• Steam sterilized: is seen to last longer and offer superior protection through its double mechanical seal.
• Special sampling & discharging valves for aseptic processes.
• Large viewing glass for real-time observation.
• Integrated ports for temperature, pH, DO sensors, and feeding/inoculation.
• Optimized diversion design for better temperature and nutrient distribution.
• Air distributor and precision rotameter for accurate gas flow.

All welds are done to be strong, neat and fine polished to 0.4-0.6um – the epitome of beauty and utility.

Fermenter Technical Specifications

Every performance and reliability that you require, at one glance:

Bottom Mechanically Agitated Fermenter Technical Parameters:

Parameter	Description
Total volume	5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 5KL, 50KL, 200KL etc.
Working volume	30%~70%
Tank	Jacket tank, made by SS316 and SS304, tank design pressure 0.3Mpa, jacket design pressure 0.35Mpa, polishing 0.4-0.6um, ratio of diameter and height is 1:2.2-2.5
Stirring system	Mechanical drive on the top/bottom or Magnetic drive on the top, 3pcs height adjustable six-blade paddle Stir speed: 50~1000rpm/50-400rpm
Sterilization	Sterilize in place(SIP), auto control by program
Clean	Clean in place (CIP) by spray ball
Gas control	Control by rotor meter, air flow 1 vvm
Feeding	Automatically feeding by peristaltic pump
Anti-foam control	Automatically add antifoam by peristaltic pump
Temperature control	Auto-control,  electric heating range: water source add 5℃ to 70℃
PH control	PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland.
Do control	0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.
Sampling	Sampling valve, can sterilization separately, manual
Harvest	Zero dead zone bottom valve(Gemu/Burket,Germany), can sterilization separately, manual/auto
Lid lift system	30L-500L have lid lift system, 700-1000L have human hole.
Pressure	Auto control, BD Germany pressure transmitter
Exhaust	Have condenser before exhaust, control by diagram valve / Proportional control valve.
Control parameters	10 or 15 inch touch screen , Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions
Optional configuration	Remote control, Mass flow meter(auto control gas), O2/N2/CO2, gas flow 2vvm, gas(CO2) exhaust analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor(Biomass), Printing, Siemens touch screen, Double mechanical seal, 4-Valves-group for feeding, Bottom valve auto discharge, ASME certificate, CSA certificate, Batch culture, Seed transfer, etc.

Smart Control with Siemens PLC

Imagine having every critical parameter at your fingertips.

• This fermenter incorporates a German Siemens S7-200 type PLC with a 10-inch LCD touchscreen:
• View real-time data (pH, DO, temp, stirring speed, gas flow)
• Automatic process control
• Historical data logging & export
• User-friendly interface in English, Chinese, and more
• Menu-driven navigation for fast learning curve

Tired of manual adjustments? Under automated control you concentrate on the results rather than on continuous watching.

Fermenter Applications

The 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB can be used:

Animal vaccine production:

• Avian influenza, PRRS, foot-and-mouth, rabies, mink vaccines
• DTP, diphtheria, tetanus

Human vaccines:

Meningitis, pneumonia IV, hepatitis B, diphtheria, tetanus

Other Fermentation Processes:

• Bacterial, fungal & yeast cultures
• Mammalian cell lines (CHO, HEK293)
• Plant cells, algae, enzymes, proteins
• Antibiotics, food additives

It can be used successfully on R&D to pilot scale due to its perfect mixture and temperature control.

Bottom Mechanical Stirring: Why It Matters

Bottom mechanical stirring ensures:

• Even distribution of heat and nutrients
• Reduced vortexing compared to top drives
• Better control for shear-sensitive organisms
• Stability at varying volumes

Ever wondered if bottom stirring fits your process? In cases in which your product will work best under even conditions, bottom stirring can be of great benefit.

 Gas & Ventilation: Deep Ventilation Done Right

• Integrated air distributor spreads gas evenly.
• Rotameter allows fine-tuned manual gas adjustment.
• Sterilizing filters (Dominic/Shanghai Yiming) with 0.2μm pore prevent contamination.
• Steam sterilized condensate cooling keeps seals lubricated and safe.
• Outcome: improved oxygen transfers rate, safer usage and a longer equipment functioning life.

Engineered for Hygiene & Durability

• All internal welds are smooth & neat.
• Polished to Ra ≤ 0.4–0.6μm, reducing contamination risk.
• Steam sterilization with automatic temperature control.
• 2-mechanical seal cooled & lubricated steam condensate.

The design reduces the time of cleaning and maintains low batch-to-batch contamination.

Process Optimization & Scalability

The 100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB is a laboratory-scale up unit:

• Equal geometry and mixing at various volumes, processes can be easily validated.
• Data logging helps refine your protocols over time.
• Remote access options let you monitor anywhere.

Ready to move from lab to pilot? This one is your over-bridge that builds 5L to 200KL systems, each one as detailed as the other.

Optional Configurations & Custom Features

Customize your fermenter to match your exact needs:

• Mass flow meter for automatic gas mixing
• CO₂ exhaust gas analysis
• Turbidity, biomass & ORP sensors
• Automatic bottom valve discharge
• Batch culture & seed transfer modes
• Double mechanical seals & 4-valve feeding groups
• Certificates: ASME, CSA for Regulatory Compliance

Such adaptability maintains your investment up to date as your process changes in the future.

 Sustainable Bioprocessing Benefits

• Lower water & cleaning agent consumption with CIP/SIP.
• Energy-efficient design.
• High durability reduces replacement needs.

By investing on quality equipment, the lifecycle cost decreases and the unscheduled startup is minimized.

Intelligent Design Features

• Large viewing window & internal light.
• Liquid level interfaces and multiple spare ports.
• Compact footprint with lid lift system.
• Zero dead zone valve for full drainage.

All of this makes your work efficient and your data reliable.

Real-World Results: What You Can Produce?

• Recombinant proteins & enzymes
• Vaccines (viral & bacterial)
• Cell culture-based products
• Algal biomass
• Organic acids & amino acids
• Antibiotics & therapeutic proteins

The fermenter is flexible regardless of whether you need food, pharma, or research products.

Quick Recap: Why It Stands Out

• Robust stainless steel build
• Bottom mechanical stirring for stable, even mixing
• Automated Siemens PLC control
• CIP & SIP for top hygiene
• Flexible volumes and applications
• Global sensor & valve brands (Hamilton, Gemu, BD, etc.)

100 Liter Stainless Steel Bottom Mechanically Agitated Fermenter BLBIO-100SJB is not only just a machine, it is a heart of your bioprocess lab.

Ready to Upgrade Your Fermentation?

Think even quicker scale-up, reduced contamination threat and wiser management of each batch.

Become familiar with BaiLun Bio, visit the company at the given contact, call today to discuss or have a quote tailored to your own requirements.