High Throughput Glass Micro Bioreactor
Over 25 years production experience
Your Reliable Chinese Micro Bioreactor Manufacturer: Bailun（BLBIO）
Bailun Biotechnology is a leading micro bioreactor manufacturer in China. Products cover all kinds of bioreactors in laboratory, pilot scale and industrial production, including fermenter, animal cell bioreactor, plant cell bioreactor, single-use bioreactor, liquid dispensing system and disposable reactor, etc. Can produce bioreactor of 0.1L-1000KL volume and technical services, and provide intelligent and personalized comprehensive solutions for bioreactors process. Bailun has a large number of experienced fermentation process, biochemical equipment and chemical technical engineers, many famous experts and scholars as the company’s technical consultants, Bailun forever pursuits to create value for customers, and adhere to customer-centric is the core value of Bailun.
High-throughput Micro Bioreactor Waterless Temperature Control
High-throughput micro bioreactor is micro fermenter.It has semiconductor anhydrous temperature control and anhydrous condensers, multi channel, high-throughput, small footprint, lightweight, and a good helper for R&D process.
High-throughput micro bioreactor does not require a drop of water, energy-saving and environmentally friendly, suitable for the different laboratories’ requirements. For good parameter control, this model maximum total volume size is 2L.
Bailun micro bioreactor Meet Various Production Needs
BLBIO-XGC-mini or BLBIOXGJ-mini (X means volume liters) series single full glass vessel micro bioreactor, magnetic(GC) or mechanical(GJ) drive on the top, off-site sterilization, program auto control fermentation parameters, easy operation and clean, small and save place. Standard model control pH/DO/foam/temperature/agitation/gas. Control panel language EN/CN/RU.
Micro bioreactor meet various purposes of fermentation, such as batch, batch fed, and for bacterial, yeast, microorganism, animal cell culture, algae etc. culture.
Micro Bioreactor Can Be Customized
10 inch color touch screen of high-throughput micro bioreactor displays all measured values and control parameters, usually each bioreactor has 4 peristaltic pumps for acid, alkali, defoamer, medium. Automatic control pH/DO/temperature/agitation/antifoam. Gas has manual control and auto control (mass flow meter) for choose. All fermentation data have history curvy and can export by U disk.High-throughput mini fermenter bioreactor accept customize and design.
High-throughput micro bioreactor have more optional: Remote control, Mass flow meter, gas O2/N2/CO2, Exhaust gas (O2/CO2) analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Glucose detection, Weight system, Live cell sensor(Biomass), Variable speed pump, Printing, 15” color touch screen, Siemens screen, program open setting etc..
Cases
Waterless temperature control bioreactor
Waterless temperature control bioreactor
mini-glass-1GJ-4-Waterless-temperature-controlled-fermenter
Know More About High-throughput Micro Bioreactor
| Parameter | Description |
| Total volume | Maximum total volume size is 2L. |
| Working volume | 30%~70% |
| The ratio between diameter and height | 1:2.0~2.3 |
| Vessel specifications and quantity | Micro fermenter quipped with 4 glass vessel systems. Maximum total volume size is 2L. The material is high temperature sterilization borosilicate glass. The tank cover distributes the inoculation port, pH electrode port, DO electrode port, 4-way feed port, temperature electrode port, and sampling port. Each tank is equipped with 2 gears Rushton stirring paddle, 1 gear axial flow oblique blade paddle, annular gas distributor, and anhydrous temperature control exhaust gas condenser. |
| Innovative water-free temperature module | Micro fermenter can be used for 4 tanks at the same time. The innovative water-free temperature control module can independently control the temperature of each tank without external cooling water auxiliary equipment, reducing the water environment around the fermentation. Temperature control range: 10~45℃; accuracy: ±0.1℃. |
| Stirring control module | Mini bioreactor can control 4 tanks at the same time, equipped with servo drive motor, speed control range: 50-1000rpm. PID control can be set for manual, automatic or cascade control. |
| DO control module | 4 high temperature sterilization DO probes, DO display control range 0.0-150.0%, accuracy: ±1.0%. Dissolved oxygen can be controlled in forward or reverse cascade through parameters/behaviors such as stirring speed, air ventilation, and feeding. Three cascade modes of parallel, series and cross can be used to achieve more precise control; |
| pH control module | for 4 tanks at the same time. The acid/alkali pump can realize linkage control with the feed pump to maintain the balance of the reactor matrix concentration. 4 high temperature sterilization pH probes. The control range is 2.00-12.00±0.01; Precision feeding pump module: 16 units, 4 watson-marlow peristaltic pumps each. Each feed pump module must be operated with independent power supply, and can be freely split and combined (non-integrated) according to the different feeding processes of each tank. Precisely control the amount of feed, realize batch, feeding, continuous and perfusion culture mode ； |
| Gas distribution module | for 4 tanks. Equipped with a rotameter to manually control the air intake, range: 0~2L/min |
| Foam/Liquid Level Control: | Foam control is realized by the foam probe sensing the liquid level and automatically adding defoamer. |
| The system of high-throughput micro Bioreactoris modular in design (non-traditional integrated), which can be split and expanded freely. Each module can run independently without interfering with each other, ensuring good repeatability and parallelism, so as to achieve rapid and accurate development of process conditions exploration. The desktop (not floor-standing) compact design of the whole machine, the size does not exceed: 1.5m*0.8m*0.9m (length, width and height) to fit the tight laboratory space. | |
| The exhaust has a water-free condenser, no external cooling water is required | |
The following picture shows the production workshop of Bailun.
Supporting Equipment
The refrigeration system of a chiller unit consists of four basic parts: compressor, condenser, throttle, and evaporator. Connect the four major components in a certain order using copper pipes to form a closed system, which is filled with a certain amount of refrigerant.
The compressor sucks in low-temperature and low-pressure Freon gas from the evaporator, compresses it into high-temperature and high-pressure Freon gas, and then flows through a thermal expansion valve (capillary tube), throttling it into a low-temperature and low-pressure Freon liquid two-phase object. Then, the low-temperature and low-pressure Freon liquid absorbs heat from indoor air in the evaporator, and the cycle of compression condensation throttling evaporation is repeated.
The Bailun steam generator uses well-known imported accessories, which are corrosion-resistant and finely crafted. Fast steam production in one minute, with a thermal efficiency of up to 100.27%. Clean steam, sufficient gas production, can provide stable steam for a long time, ensuring the required heat energy during the drying process. Advanced vertical cross flow structure, using 12Cr1MoVG high-pressure boiler steel and stainless steel laser fins with extremely high heat transfer efficiency, no explosion risk, safer equipment, and better steam quality.
Bailun air compressor is an oil-free and silent air compressor equipped with a domestically produced powerful air pump and a gas tank with built-in anti-corrosion coating. It has a high cost performance and is used as a supporting equipment for bioreactors. Has the following characteristics:
● Independently produce machine heads and components;
The machine is equipped with multiple automatic protection systems for safer use;
● Easy to operate, ready to use upon power connection, automated design, no need for dedicated personnel to operate the work;
●Low noise during work, original oil-free piston system, high efficiency, low loss, and clean gas discharge;
●Optional double-layer vacuum drying and filtering equipment to meet the supply of high-purity air source and protect user equipment;
Other Products
Cleaning, maintenance and care of the fermenter tank
Cleaning
- The fermenter tank body is the place that comes into direct contact with the material. The degree of its surface finish and the cleanliness of its internal components are factors that directly affect the contamination. Therefore, the tank body and related equipment must be cleaned in time after each fermentation and before reuse. When cleaning, attention should be paid to the electrical components and electrode interfaces, and water and moisture should not be allowed to enter.
- PH and DO electrodes should be taken out before cleaning and maintained according to their requirements.
- The tank can be cleaned together with water intake, air intake, motor stirring and heating. If it cannot be cleaned after multiple water changes, the top cover should be opened and the internal parts of the tank should be brushed with a soft brush. The method is as follows: control the switch and the power switch, remove the top cover electrode, motor and its connection plug. Unplug the air intake hose condenser quick connector and remove the air intake filter upper hose and connector; remove the top cover together with the stirring vertically upward, and place it horizontally on a flat table, pad it well, do not hit the shaft and impeller, and use a neutral detergent to brush the tank body and internal parts.
- Note: When moving and cleaning the tank cover, only the shaft sleeve or top cover can be grasped, and the stirring shaft, impeller and other easily deformed parts cannot be grasped. While cleaning, the tank and outlet valve and other O-rings should be checked. If deformation, aging, scratches, etc. are found, they should be replaced in time. After cleaning and reinstalling, the surface and tank rack should be wiped dry with a rag. Tighten the six fastening screws of the tank cover, use balanced force and pay attention to the balance of the gap between the tank and the tank seat. Be especially careful when cleaning the glass fermentation tank, and do not collide during disassembly and assembly; when tightening the fastening screws of the tank cover, the force must be balanced and pay attention to the balance of the gap to avoid damaging the glass tank body.
Maintenance of the stirring system
- The stirring system includes the stirring shaft, stirring paddle, mechanical seal. Bearings, couplings and motors, etc.
- Daily maintenance: Regularly check the operation of the stirring shaft, the heating of the motor and the emission of abnormal noise, and regularly check whether the relevant bolts are loose.
- Check the wear of the mechanical seal every year to ensure the normal operation of the mechanical seal and avoid unnecessary contamination.
- If a double-end mechanical seal is used, always pay attention to the changes in the sterile water level. If the liquid level drops, it means that the seal gap is leaking, which should be handled immediately after the fermentation is completed.
- Check the wear of the oil seal and the carbon brush of the motor, as well as the wear of the oil seal and the bearing every year.
Maintenance and care of sterilized air system
- The sterilized air system includes air compressor, coarse filter, fine filter, diaphragm valve and air distributor, etc.
- In daily maintenance, attention should be paid to the operation of the air compressor. During the fermentation process, the drain valve of the air storage tank should be drained twice a day. Maintenance and care of the filter The sterilization temperature should be controlled below 125℃
- During the sterilization process, attention should be paid to the sterilization temperature of the filter should be controlled below 125℃. Because the filter material will fall off at too high a temperature, the binder will make the filter ineffective.
- Replacement of filter element.
- Because the air contains a lot of dust, the micropores of the filter element will gradually become blocked after the filter has been used for a period of time. On the one hand, this will increase the resistance, causing serious lack of air flow and increased air pressure drop, thereby affecting the ventilation volume, and may cause bacterial contamination. At this time, it needs to be replaced.
- Due to the large differences in air quality in various places, there is no accurate service life, which can generally reach more than 6 months. The replacement standard is that the minimum air flow is not less than 1.5 times the volume of the tank. (The pressure difference between the pressure reducer outlet and the tank pressure is not less than 1kg/cm2)
- After each fermentation, the air distributor needs to be cleaned. If the properties of the fermentation liquid are similar to water, water can be added to the tank and then compressed air can be passed through for cleaning. If the fermentation liquid is viscous or contains fine particles, it is best to remove the air distributor, unscrew the plug, and rinse with water. At the same time, ensure that the small holes are ventilated smoothly.
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Our Advantages
Extensive experience and expertise
We have many years of experience in the industry and accumulated a wealthof professional knowledge to provide customers with the best quality products and services.
Diverse product lines
We provide products in the field of bioreactor (fermenter) andcomplete control system to provide customers with a full range of solutions.
Strict quality control.
We have always adhered to strict quality management and technological innovation to ensure that our products are always in the leading positionin the industry.
Customer first service concept.
We always stand on the customer's point of view, starting from the customer's needs, to provide customers with the best solution. No matter what customers need, we will meet their needs with a professional attitude and high-quality products.
