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Abstract Bioreactor technology is widely used in cell culture-based viral vaccine production. Especially during the COVID-19 pandemic, its development and application enabled efficient and low-cost vaccine manufacturing to meet global vaccine demand. Starting from the classification of viral vaccines and animal cell lines used in vaccine production, this paper introduces the main types of bioreactors, […]

When biopharmaceutical production line equipment breaks down, it can seriously damage work efficiency and product quality. There are even cases where such issues delay the supply of biopharmaceutical goods. For companies in the biopharmaceutical industry, preventing faults is therefore of great importance. Six Sigma works as a practical management method. It can provide comprehensive support

In recent years, driven by innovations in cutting-edge biotechnology and the continuous development of the industrial biotechnology industry, the role and advantages of dynamic regulation strategies have become increasingly prominent in the field of metabolic engineering. To timely balance the relationship between gene expression required for product synthesis and global metabolic levels, the introduction of

I. System Design Principle and Composition A biological process refers to the biochemical reaction carried out by a biological system inside a bioreactor. The biological system and its surrounding environment in the bioreactor form a relatively closed ecosystem. In this ecosystem, there are interactions between the biological system and environmental factors. For a biological system,

This paper studies the synthetic biomanufacturing of propionic acid. It reviews research progress in biomanufacturing in detail. It discusses metabolic engineering of propionibacteria. It also discusses pathway construction in non-native hosts. It further describes bioconversion production using Pseudomonas. The paper gives technical routes and strategies for sustainable propionic acid production. Importance of Propionic Acid and

Hydrogen production through microbial fermentation in bioreactors is a common industrial method. Now, the anaerobic fluidized bed bioreactor (AFBR) is one of the most effective reactors for biological fermentation-based hydrogen production. The microbial film is formed by the natural adhesion of microorganisms to carrier particles. The fluidized bed structure lets the reactor retain a large

Problems can arise in any part of the fermentation tank and its auxiliary equipment. These equipment include air purification systems, control systems for temperature, pressure, flow rate, and corresponding pipelines and valves. Such problems may lead to fermentation failure. Enterprises should first establish a prevention-oriented concept. They should eliminate all potential hidden dangers of fermentation contamination.

As the most potent antioxidant in nature, astaxanthin exhibits antioxidant, anti-inflammatory, and anti-photoaging properties. It plays a crucial role in delaying human aging, preventing and alleviating inflammation, and improving skin photoaging. However, free astaxanthin suffers from poor stability, low water solubility, and low bioavailability. Developing astaxanthin carriers with high stability, good water solubility, and non-toxicity

In the process of penicillin fermentation, the maximum biological yield is usually achieved by screening superior strains, regulating biological processes such as the metabolic development and growth of bacterial cells, and providing the optimal pH, temperature, as well as carbon and nitrogen sources in the fermentation broth. These control conditions, along with various biological, physical-chemical

Cell and gene therapy represents a revolution in pharmaceuticals and clinical treatment technology, enabling the cure of diseases at the molecular level for humans. 一、Cell and Gene Therapy Technology Cell and Gene Therapy (CGT) refers to a treatment method that replaces or supplements defective genes in patients with normally functioning ones to cure diseases; alternatively,