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As the most commonly used eukaryotic unicellular microorganisms, yeasts exhibit rapid growth and reproduction, and relatively simple genetic manipulation. Compared with prokaryotic expression hosts, Yeasts have greater advantages in heterologous enzyme expression, thus attracting extensive attention from researchers in the application of biosynthesis. In contrast to Saccharomyces cerevisiae, non-conventional yeasts possess unique physiological and metabolic advantages […]

Gas liquid mass transfer in bioreactors is affected by many factors. Diffusion coefficient, liquid-phase density, and fluid viscosity are intrinsic parameters of the fluid. They leave little room for changes in studies on intensifying gas liquid mass transfer. So, turbulent kinetic energy dissipation rate, bubble diameter, local gas holdup, and surface tension are the main research targets

An animal cell bioreactor is a system that copies the living environment of animals for cell culture outside the body. It is a high-tech system that combines mechanics, fluid flow, control engineering, and biotechnology. The main goal is to grow cells at high density and to produce useful medical products, such as enzymes, monoclonal antibodies,

Pichia pastoris is a type of methylotrophic yeast that can utilize methanol as its sole carbon and energy source. Like other yeasts, it exists mainly in the haploid form during the asexual growth phase. When environmental nutrients are limited, it often induces the mating of two haploid cells of different physiological mating types, which fuse

Fermentation of traditional Chinese medicine is not a new concept. Its history can be traced back to ancient times. In the past, people often placed Chinese medicinal herbs in earthenware jars for fermentation. Traditional fermentation has many drawbacks. For example, it is hard to precisely control the fermentation process. Product quality is also unstable. Modern

Whether a factory can make a profit, whether its products are reliable, and whether it can expand its scale – these largely depend on its “capabilities”. Specifically, its significance is reflected in the following aspects: 1、Cut costs and boost efficiency for factories Biomanufacturing relies on microorganisms to “consume raw materials and produce products”. High-performance strains

An authoritative review published in Chemical Engineering & Technology systematically sorts out the core control strategies of fermentation processes, from basic open-loop to advanced intelligent control, providing a clear technical blueprint for industrial production. This review paper, published in Chemical Engineering Technology, systematically summarizes the core challenges and technological frontiers of fermentation process control. The difficulty in controlling

1.Fed batch fermentation is a core technology in fermentation production. It is crucial for achieving efficient product accumulation. Its core value is to balance the concentration of various substances in the fermentation system through scientific regulation. It avoids substrate inhibition or catabolite repression. It maintains the fermentation process in an optimal state at all times.

 (I) Rapid Breakthroughs in Key Technologies Gene Editing Technologies The rise and steady improvement of gene-editing technologies like CRISPR-Cas9 have made it possible for scientists to change and adjust genes with much higher accuracy and efficiency. This gives strong tools for building biological systems with clear functions in synthetic biology. These tools also shorten research

The competition in semaglutide active pharmaceutical ingredient (API) has shifted from “who expands fastest” to “who builds strength”. The differentiation of the three major echelons marks the semaglutide industry’s entry into a new stage driven by capabilities. In the future, only enterprises with scale, technology, cost control and industrial chain synergy can gain a foothold