100 Liter mammalian cell fermenter BLBIO-100SCUC

Have you ever wondered how it would feel to operate your mammalian cell cultures by the use of equipment that promises reproducible results, precision control, and endures the demands of current high technology biotechnology? Let’s dive in.

An Introduction to Modern Fermentation Excellence

The 100 Liter mammalian cell fermenter BLBIO-100SCUC is purpose-built to support the complex requirements of mammalian cell culture, including hybridoma cells, CHO cells, insect cells, and many others. With the battle between reproducibility and process efficiency deciding who wins the race against research and industrial production in the world of biotech nowadays, this fermenter stands the difference.

Designed with the best structural attributes, it offers ultra-performance and has features that meet functionality, adaptability, and ease of use.

Why Choose the Stainless Steel Design?

 

This fermenter is made of high quality 316L stainless steel featuring 304 stainless steel clips and provides the following:

• High corrosion resistance, critical for cleanroom and GMP environments.
• Internal surface with polished finish of 0.2-0.4um, allowed a reduced chance of contamination and easy cleaning.
• Polishing the surface in order to come up with the beauty of a professional finish that shows quality.
• The level of smart design it flaunts (blind spots are avoided, even within the tank) make it easier to clean to keep it sterile between run batches and shorten downtime.

Are you wasting your time as far as maintaining and cleaning are concerned? A smarter tank design could save you hours.

Performance Driven by Precise Engineering

At the heart of the 100 Liter mammalian cell fermenter BLBIO-100SCUC is a suite of features engineered for performance:

• Low shear mixing blades eliminate the possibility of damage to small cells such as delicate mammalian cells, which is a major advantage of this method of stirring.
• It has variable stirring speed of 30 -300 rpm which complies with varying culture demands.
• The occurrence of contamination is also minimized by the integrated cooling systems and exhaust pathways which have a special designed exhaust pipe ensuring the purity of your cultures.

Does your system right now safeguard your cell integrity when you mix it? This fermenter is built to do exactly that.

Control Systems for Complete Process Oversight

The Siemens S7-200 series PLC and large touch screen interface (10 or 15 inches) provide:

• Availability of real time information and room to perform necessary adjustments such as pH, DO, temperature, and gas flow among others.
• Full menu-driven operation in English, Russian, or Chinese.
• Instead, its strong data logging and data analysis capabilities that transform raw data into the actionable ones.

Whole new level of confidence when you can see the performance of your processes on your crystal clear interface, and warnings when important parameters are drifting. Wouldn’t that simplify your daily operation?

Key Specifications You Can Trust

Let’s explore the technical heart of the 100 Liter mammalian cell fermenter BLBIO-100SCUC:

Parameter	Description
Total volume	5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 5KL, 10KL etc.
Working volume	30%~70%
Tank	Inside electrolytic polishing, precision: 0.2-0.4um. Diameter and height ratio 1:1.5
Stirring system	Magnetic drive, low shear mixing blades. Stir speed: 30~300rpm
Sterilization	Sterilize in place (SIP), auto control by program
Clean	Clean in place by spray ball
Gas control	Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2) Auto control by mass flow meter. Air flow 1vvm, O2/N2/CO2  0.1vvm.
Feeding	Automatically feeding by peristaltic pump
Anti-foam control	Automatically add antifoamer by peristaltic pump
Temperature control	Auto-control, electric heating range: water source add 5℃ to 70℃
PH control	PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland.
Do control	0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.
Sampling valve	Can sterilization separately, manual
Harvest	Zero dead zone bottom valve, can sterilization separately, manual
Weight system	Mettler-Toledo, Switzerland
Pressure	Auto control, BD Germany pressure transmitter or Lambert differential pressure liquid level gauge.
Exhaust	Have condenser before exhaust, control by diagram valve / Proportional control valve.
Control parameters	10 or 15 inch touch screen, Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions
Optional configuration	Remote control, Mass flow meter(auto control gas), exhaust heating, exhaust filter, gas(CO2) exhaust analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor（Biomass）, Printing, Siemens touch screen, Double mechanical seal, 4-valves-group for feeding, Bottom valve auto, ASME certificate, CSA certificate, air flow 2vvm, etc.

A System Designed to Adapt

In biotechnology, your needs can change rapidly. The 100 Liter mammalian cell fermenter BLBIO-100SCUC offers modular options:

• Remote control to manage your process anywhere.
• sophisticated sensors with which to measure the density of live cell density, ORP, or turbidity.
• Exhaust gas analysis for deeper process understanding.
• Custom bottom valves or multi-feed lines of difficult processes.

What would you do, were your process to change tomorrow and could your equipment keep up?

Safety and Reliability First

Safety features include:

• Zero dead zone bottom valve, eliminating residue accumulation.
• Sterilization-separable systems of manual sampling and harvest.
• Pressure sensors and safety lamps that enhance monitoring.

So with these the system does not merely work, it works safely batch after batch.

Applications That Go Beyond the Ordinary

Where can you use the 100 Liter mammalian cell fermenter BLBIO-100SCUC?

• Production of monoclonal antibodies from hybridoma cells.
• Recombinant protein drug manufacturing with CHO cells.
• Viral vaccine production through high-density culture.
• Academic research and pilot-scale testing before industrial scale-up.

Be it expands or using new cell lines, this fermenter helps.

Why Gentle Mixing Matters?

In mammalian cells, the shear stress may damage the quality and the viability of the product. The magnetic drive mixing system provides:

• Smooth, low-shear mixing ideal for suspension cell cultures.
• Uniform distribution of nutrients and gases.
• Flexibility to adapt speeds as cell density changes.

Do you struggle with low viability or inconsistent yields? A properly designed mixing system makes the difference.

Built for Sterility and Compliance

Using CIP and SIP systems: the fermenter will always be available to your next run:

• Automated cleaning and sterilization reduce manual work.
• Compliant design helps meet GMP requirements.
• Smooth, polished surfaces leave nowhere for contaminants to hide.

Could automated cleaning reduce your downtime and increase output?

User-Friendly Digital Platform

Siemens control system helps more than sustaining processes:

• Historical curve analysis helps spot trends.
• Alarm systems alert you before problems escalate.
• Data export keeps your quality records audit-ready.

Consider yourself having to answer questions with real-time and past data – quicker, more confident.

External Design Details That Matter

External design isn’t just aesthetic:

• Large sight glasses provide visual confirmation of liquid levels.
• Delay-type Philips safety lamps improve visibility during operation.
• Optimized exhaust systems protect against contamination and save heat.

Would not these be convenient features that would make your daily operation smooth and safe?

Supporting Large-Scale Production

The design isn’t just for lab-scale work:

• It scales seamlessly to 5KL, 10KL, and beyond.
• The same core control philosophy and quality materials.
• Modular configurations keep your facility ready for tomorrow’s demand.

Ready to grow your process? This fermenter grows with you.

The Power of Data in Your Hands

Data transforms fermentation from art into science:

• Record all pH, all gas and temperature changes.
• Use built-in analytics to refine your next batch.
• Reduce variability and enhance consistency.

Did you think about the possibility of better data to double your reproducibility and yields?

Precision Meets Flexibility

Every process is unique, and your fermenter should adapt:

• Switch between batch, fed-batch, or perfusion processes.
• Configure gas mixes dynamically.
• Adjust feeding strategies for growth and production phases.

How much more would your team be able to do with that sort of leeway?

Support

BaiLun Bio offers:

• Ongoing technical support.
• Customization services to match your process.

Try not to think about purchasing equipment per se, but having a stakeholder who will wish and take care of your success.

Sustainability in Bioprocessing

The fermenter helps sustainability by:

• Lowering energy costs through efficient heating/cooling.
• Minimizing product losses with better monitoring.
• Extending lifespan with robust stainless steel construction.

How would increase sustainability of operations affect your profits?

In Summary: Why Invest in This Fermenter?

• Robust 316L stainless steel design.
• Smart mixing for fragile mammalian cells.
• Advanced Siemens PLC with user-friendly interface.
• Flexible configurations and modular expansion.
• Proven track record in vaccine, antibody, and protein production.

Wouldn’t your process benefit from such reliability and control?

Make Your Next Step

The 100 Liter mammalian cell fermenter BLBIO-100SCUC isn’t just equipment; it’s your partner in pushing bioprocess limits, improving yields, and ensuring consistent, reproducible results.

Ready to elevate your cell culture process? Contact BaiLun Bio now and find out how this fermenter meets your requirements – and get on the way to smarter, more efficient, and scalable bio manufacturing.