Mammalian Cell Culture Bioreactor Manufacturer for Biopharmaceutical Production
Glass bioreactors: 1L–30L
Stainless steel bioreactors: 5L–10KL
Low-shear cell culture design
GMP-ready production systems
25+ Years Bioreactor Manufacturing Experience
Exported to 30+ Countries
CE / ISO Certified
Complete One-stop Station Fermentation Solutions
Our Mammalian Cell Culture Bioreactor Solutions
We offer bioreactors (fermenters), animal cell bioreactors, bioreactor shakers, biological shakers, bottle rockers, and control systems, and recognize validation services are essential for meeting regulatory and operational requirements of fermenters and bioreactors.
Low-Shear Cell Culture Design
•Marine impeller design
•Elephant-ear impeller option
•Low-speed agitation
•Gentle gas distribution
•Uniform nutrient mixing
Excellent Oxygen Transfer Performance
•High oxygen transfer efficiency
•Reduced bubble damage
•Multi-gas blending capability
•Stable DO control
•Improved cell density
Accurate Environmental Control
•Temperature
•pH
•Dissolved Oxygen (DO)
•Agitation
•Gas flow
•Feeding strategy
Intelligent Automation Platform
•Siemens PLC control system
•15-inch industrial touchscreen
•Recipe management
•Trend display
•Historical data storage
•SCADA integration
•Remote access optional
Mammalian Cell Culture Bioreactor Applications
We offer bioreactors (fermenters), animal cell bioreactors, bioreactor shakers, biological shakers, bottle rockers, and control systems, and recognize validation services are essential for meeting regulatory and operational requirements of fermenters and bioreactors.
| Parameter | Description |
| Total volume | Glass bioreactor 1L~40L ,stainless steel bioreactor 5L~10KL; |
| Working volume | 30%~70% |
| Tank | Glass bioreactor:glass wall with stainless steel lid and bottom, heating from jacket stainless steel bottom.Stainless steel bioreactor:inside electrolytic polishing, precision: 0.2-0.4um. Diameter and height ratio 1:1.5 |
| Stirring system | Magnetic drive, low shear mixing blades. Stir speed: glass bioreactor 50~300rpm ,stainless steel bioreactor 30~300rpm |
| Sterilization | Stainless steel bioreactor: sterilize in place (SIP), auto control by program;Glass bioreactor: off-site sterilization(Autoclave) |
| Clean | Stainless steel bioreactor clean in place by spray ball |
| Gas control | Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2)Auto control by mass flow meter. Air flow 1vvm, O2/N2/CO2 0.1vvm. |
| Feeding | Automatically feeding by peristaltic pump |
| Anti-foam control | Automatically add antifoamer by peristaltic pump |
| Temperature control | Auto-control, electric heating range: water source add 5℃ to 70℃ |
| PH control | PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland. |
| Do control | 0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen. |
| Sampling valve | Can sterilization separately, manual |
| Harvest | Stainless steel bioreactor zero dead zone bottom valve, can sterilization separately, manual |
| Weight system | Stainless steel bioreactor Mettler-Toledo, Switzerland |
| Pressure | Stainless steel bioreactor auto control, BD Germany pressure transmitter or Lambert differential pressure liquid level gauge. |
| Exhaust | Stainless steel bioreactor have condenser before exhaust, control by diagram valve / Proportional control valve. |
| Control parameters | 10 or 15 inch touch screen, Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions |
| Optional configuration | Remote control, Mass flow meter(auto control gas), exhaust heating, exhaust filter, gas(CO2) exhaust analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor（Biomass）, Printing, Siemens touch screen, Double mechanical seal, 4-valves-group for feeding, Bottom valve auto, ASME certificate, CSA certificate, air flow 2vvm, etc. |
Why Not Other Suppliers
Customer Projects
Biotechnology Company
Biopharmaceutical Company
Vaccine Manufacturing Facility
Contract Manufacturing Organization
