Screen High Flux Liquid Handing System is to partition single nucleic acid template into separate reaction chambers and performs a single molecule quantification by PCR amplification and fluorescence signal detection. The digital PCR technology does not reply on neither Ct values nor standard calibration curves, and has extremely high sensitivity, precision, and excellent repeatability. It is an absolute quantitative analysis technology that transcends real-time PCR.
150L GMP Vaccine Bioreactor for Pilot-Scale Biopharma Production
Bailun’s 150L GMP Vaccine Bioreactor is specifically designed for pilot-scale vaccine production, biologics development, and GMP biopharmaceutical process optimization. The system combines advanced automation, precise process control, and GMP-compliant engineering to support scalable and reproducible upstream bioprocessing.
This pilot biopharma system is ideal for vaccine manufacturers, CDMOs, biotechnology companies, and pharmaceutical research institutes requiring reliable process scale-up from laboratory development to pilot production.
Applications of 150L GMP Vaccine Bioreactor
The 150L GMP bioreactor is suitable for a wide range of biopharmaceutical and vaccine production applications, including:
Viral Vaccine Production
mRNA Vaccine Manufacturing
Recombinant Protein Expression
Monoclonal Antibody (mAb) Production
Mammalian Cell Culture
Microbial Fermentation
Cell & Gene Therapy
Upstream Bioprocess Development
Pilot-Scale Biopharma Production
Process Scale-Up Studies
The system is optimized for both microbial and mammalian cell cultivation with high process stability and sterility assurance.
Key Features of the 150L GMP Vaccine Bioreactor
GMP-Compliant Bioreactor Design
The 150L vaccine bioreactor is engineered according to GMP pharmaceutical manufacturing standards, supporting FDA and EMA compliance requirements.
Features include:
Electropolished stainless steel vessel
Hygienic piping design
Zero-dead zone structure
Aseptic connections and valves
Full traceability and documentation support
Integrated SIP & CIP System
The system includes fully integrated:
SIP (Steam-In-Place)
CIP (Clean-In-Place)
functions for reliable sterilization and cleaning between batches.
Benefits include:
Reduced contamination risk
Improved batch consistency
Lower manual cleaning workload
Enhanced sterility assurance
Advanced Process Control System
The bioreactor is equipped with a high-performance PLC/SCADA automation platform for precise monitoring and control of critical process parameters:
pH
Dissolved Oxygen (DO)
Temperature
Agitation speed
Airflow and gas mixing
Foam control
Pressure
Optional automation platforms include:
Siemens
Rockwell
Delta
High Oxygen Transfer Efficiency
The 150L pilot bioreactor features optimized agitation and aeration design for enhanced oxygen transfer performance.
Key advantages:
High kLa performance
Improved cell density
Better nutrient distribution
Stable shear environment
Enhanced production yield
Suitable for:
Mammalian cell culture
Suspension cell cultivation
High-density microbial fermentation
21 CFR Part 11 Ready
The control system supports data integrity and electronic record compliance through:
Audit trail functionality
Electronic signatures
Batch recording
User access management
Historical data storage
This makes the system suitable for regulated GMP production environments.
Designed for Pilot-Scale Vaccine Manufacturing
The 150L GMP vaccine bioreactor is designed to bridge the gap between laboratory-scale R&D and commercial manufacturing.
Typical applications include:
Production Stage | Application |
|---|---|
Lab Development | Process feasibility studies |
Pilot Production | Scale-up optimization |
GMP Validation | Clinical production |
Commercial Preparation | Process transfer support |
The scalable design ensures smooth transition to larger production volumes such as 200L, 500L, 1000L, 5000L and beyond.
Sterility and Contamination Control
Biopharmaceutical manufacturing requires strict contamination prevention. Bailun’s GMP bioreactor system includes multiple sterility protection features:
Fully closed aseptic system
SIP sterilization validation
Sterile sampling system
HEPA-grade gas filtration
Aseptic inoculation and feeding
Pneumatic diaphragm valves
Condensation exhaust management
These features help ensure product safety, batch reproducibility, and GMP compliance.
Customizable Pilot Biopharma System
Every vaccine production process is different. Bailun offers flexible customization options for pilot-scale bioprocessing requirements.
Customization options include:
Vessel Configuration
Stainless steel vessel
Hybrid glass-stainless system
Jacketed vessel with insulation design
Agitation Options
Rushton impeller
Marine impeller
Segment impeller
Low-shear agitation design
Sensor Configuration
Optical DO sensor
pH sensor
ORP sensor
Turbidity sensor/OD optical density
Biomass monitoring
Automation Expansion
Remote monitoring
Cloud data management
Advantages of Bailun 150L GMP Vaccine Bioreactor
Reliable GMP Engineering
Bailun provides GMP-compliant bioreactor systems designed for pharmaceutical manufacturing and regulated production environments.
Flexible Scale-Up Capability
The 150L system is ideal for process transfer and scale-up studies from bench-top development to industrial production.
Advanced Automation
Integrated PLC/SCADA control ensures precise process management and reproducible production performance.
Global Technical Support
Bailun supports customers worldwide with:
Installation
Commissioning
FAT/SAT support
Validation documentation
Technical training
After-sales service
Technical Specifications of 150L GMP Vaccine Bioreactor
Parameter | Specification |
|---|---|
Total Volume | 150L |
Working Volume | 45–120L |
Vessel | SS316L/SS304 vessel with sight glass |
Sterilization | Auto control SIP |
Clean | Clean in situ CIP by spray ball |
Control System | PLC/SCADA |
Agitation Type | Mechanical or Magnetic Drive |
Temperature Control | Automatic |
Feeding Control | Automatic |
Anti-Foam Control | Automatic |
pH Control | Automatic |
DO Control | Automatic |
Compliance | GMP / FDA / 21 CFR Part 11 |
Application | Vaccine / Biopharma Production |
Why Choose Bailun
Bailun specializes in advanced bioreactor and fermentation systems for biotechnology and pharmaceutical industries.
Why customers choose Bailun:
Strong customization capability
GMP-compliant engineering
Competitive global pricing
Scalable bioprocess solutions
Fast delivery
Professional technical support
Experience in vaccine and biologics projects
Frequently Asked Questions
What is the main application of the 150L GMP vaccine bioreactor?
The system is primarily used for pilot-scale vaccine production, biologics development, mammalian cell culture, and GMP biopharmaceutical manufacturing.
Can the system support both microbial and mammalian cell culture?
Yes. The bioreactor is optimized for both microbial fermentation and mammalian cell cultivation with flexible agitation and aeration configurations.
Is the bioreactor GMP compliant?
Yes. The system is designed according to GMP requirements and supports FDA, EMA, and 21 CFR Part 11 compliance standards.
Does the system include SIP and CIP functions?
Yes. Integrated SIP and CIP systems are included for sterilization and automated cleaning.
Can the bioreactor be customized?
Yes. Bailun offers customized vessel design, automation systems, sensors, agitation methods, and process configurations according to customer requirements.
Request a Quote
Looking for a reliable 150L GMP vaccine bioreactor for pilot biopharma production?
Contact Bailun today for:
Customized bioreactor solutions
Technical consultation
Detailed quotation
Pilot-scale process support
GMP bioprocess engineering services
Our engineering team is ready to help optimize your vaccine and biologics manufacturing process.